PATHOMA 2017 SYSTEMIC PATHOLOGY VIDEOS WILL BE UPLOADED SATURDAY
i don’t have to describe pathoma .because everyone knows about this great pathology book.be with this site for more unbelievable USMLE, FMGE study materials
let’s grab some stuff from the book some basic concepts that we really need to know
What are steps of neutorphil exit? What proteins are key in each step?
Margination – Usually, heavy particles in blood are in center of vessel lumen. When blood
vessel dilates, heavy particles come to edge of vessel and this is margination. It’s first step of neutrophil arrival.
Rolling – endothelial cells express proteins called selectins which act as speed bump so that neutrophils roll and slow down.
Adhesion – cellular adhesion molecules (CAM) on endothelium binds to integrins on
neutrophil resulting in adhesion. (HY)
Transmigration and chemotaxis – transmigration happens across vessel wall of postcapillary venules, and chemotaxis is a movement to infection site after transmigration. Neutrophils are attracted by bacterial products, IL8, C5a and LTB4
Phagocytosis – enhanced by opsonins (IgG and C3b)
You can start to download the pathoma lecture notes here
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