The Washington Manual Subspecialty Consult Series: Hematology/Oncology Subspecialty Consult PDF download
The Washington Manual Subspecialty Consult Series: Hematology/Oncology Subspecialty Consult PDF download Hematologic diseases are a heterogeneous group of diseases that can have multiple clinical and laboratory manifestations that mimic nonhematologic diseases.
History, physical exam, labs, peripheral smear, and bone marrow biopsy are critical in making the correct diagnosis. The diseases can be approached by identifying the primary hematologic component that is affected: RBCs, WBCs, platelets, or the coagulation system.
The major abnormalities in hematology are quantitative in nature, with either excessive or deficient production of one of the hematopoietic constituents (e.g., leukemias, anemias). Qualitative abnormalities that can be inherited (e.g., sickle cell disease) or acquired also occur.
The clinician should be comfortable using the complete blood count (CBC) and peripheral smear to evaluate patients for possible hematologic disorders. Patients may be referred to a hematologist based on a lab abnormality that is drawn for a reason other than the diagnosis of a primary hematologic disorder. There are certainlimiting values in hematology that can help exclude or confirm the need for further testing or warn us of the possibility of potential physiological consequences