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USMLE STEP 2 CK PLATINUM NOTES The Complete Preparatory Guide Second Edition Download free

USMLE STEP 2 CK PLATINUM NOTES The Complete Preparatory Guide Second Edition Download free

USMLE STEP 2 CK PLATINUM NOTES The Complete Preparatory Guide Second Edition Download free

USMLE STEP 2 CK PLATINUM NOTES The Complete Preparatory Guide Second Edition Download free  Zinc is an integral component of many metalloenzymes in the body
• It is involved in the synthesis and stabilization of proteins, DNA, and RNA and plays a structural role in ribosomes and
membranes
• Zinc is necessary for the binding of steroid hormone receptors and several other transcription factors to DNA and thereby plays an
important role in the regulation of gene transcription
• Zinc is absolutely required for normal spermatogenesis, fetal growth, and embryonic development
• Deficiency: Mild zinc deficiency has been described in many diseases including:
– Diabetes mellitus
– AIDS
– Cirrhosis
– Alcoholism
– Inflammatory bowel disease
– Malabsorption syndromes and
– Sickle-cell anemia
Mild chronic zinc deficiency can cause stunted growth in children, decreased taste sensation (hypogusia), impaired immune
function, and night blindness due to impaired conversion of retinol to retinaldehyde
Severe chronic zinc deficiency has been described as a cause of hypogonadism and dwarfism in several Middle-Eastern countries.
In these children, hypopigmented hair is also part of the syndrome ‘Acrodermatitis enteropathica’
It is a rare autosomal recessive disorder characterized by abnormalities in zinc absorption. Clinical manifestations include diarrhea,  alopecia, muscle wasting, depression, irritability, and a rash involving the extremities, face, and perineum.

The rash is .characterized by vesicular and pustular crusting with scaling and erythema. In addition, hypopigmentation and corneal edema  have been described in these patients
• The diagnosis of zinc deficiency is usually made by ↓serum zinc level
• Pregnancy and birth-control pills may cause a slight depression in serum zinc levels, and hypoalbuminemia from any cause can  result in hypozincemia

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