A.K SETHIA Pathology handwritten notes for NEET-PG/MCI Exam Preparations
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NEET-PG Golden Points
Starry Sky Patten in Biopsy
Starry sky pattern on biopsy is suggestive of Burkitt lymphoma. All forms of Burkitt lymphoma are associated with translocations of c-MYC gene on chromosome 8.
30% of childhood NHL’s
Mature B cell lymphoma
Responds well to intensive chemotherapy
High mitotic index
Contains numerous apoptotic cells
Abundant clear cytoplasm
Starry sky pattern of cytoplasm
Express surface IgM, CD19, CD20, CD10, BCL6
Fails to express anti-apoptotic protein BCL2
5) Molecular pathogenesis:
Associated with translocations of c-MYC gene on chromosome 8.
Translocation partner is usually IgH locus
6) Clinical manifestations:
Endemic: Mass involving mandible
Sporadic: Mass involving ileocecum and peritoneum
Intensive combination chemotherapy regimens High doses of cyclophosphamide
Prophylactic therapy to CNS
Ref: Robbins 9/e p 597