A.K SETHIA Pathology handwritten notes for NEET-PG/MCI Exam Preparations

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A.K SETHIA Pathology handwritten notes for NEET-PG/MCI Exam Preparations

A.K SETHIA Pathology handwritten notes for NEET-PG/MCI Exam Preparations
A.K SETHIA Pathology handwritten notes for NEET-PG/MCI Exam Preparations

Hi Currently Getting PG seats in indIn is not easy as we thought , it’s really difficult to practice the Specialty that you like in India now in this post , you can download A.K SETHIA Pathology handwritten notes for NEET-PG/MCI Exam Preparations Directly from Google Drive without any Redirects.

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NEET-PG Golden Points

Starry Sky Patten in Biopsy

Starry sky pattern on biopsy is suggestive of Burkitt lymphoma. All forms of Burkitt lymphoma are associated with translocations of c-MYC gene on chromosome 8.

BURKITT LYMPHOMA

1) Features:
30% of childhood NHL’s
Mature B cell lymphoma
Very aggressive
Responds well to intensive chemotherapy

2) Types:
African
Sporadic
HIV associated

3) Morphology:
High mitotic index
Contains numerous apoptotic cells
Abundant clear cytoplasm
Starry sky pattern of cytoplasm

4) Immunophenotype:
Express surface IgM, CD19, CD20, CD10, BCL6
Fails to express anti-apoptotic protein BCL2

5) Molecular pathogenesis:
Associated with translocations of c-MYC gene on chromosome 8.
Translocation partner is usually IgH locus

6) Clinical manifestations:
Extranodal sites

Endemic: Mass involving mandible
Sporadic: Mass involving ileocecum and peritoneum

7) Treatment:
Intensive combination chemotherapy regimens High doses of cyclophosphamide
Prophylactic therapy to CNS

Ref: Robbins 9/e p 597