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Principles and Practice of Surgery Seventh Edition
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To increase the chances of surviving injury, all animals have a complex set of mechanisms that act locally and systemically to restore the body to its preinjury condition. While these mechanisms are vital for survival in the wild, in the context of surgical injury they can be harmful.
By minimizing and manipulating the metabolic response to injury, surgical mortality, morbidity and recovery times can be greatly improved.
An understanding of the metabolic response to injury is therefore fundamental to modern surgical practice. Reduction of the metabolic (or stress) response to surgery has improved clinical outcomes in surgical patients.