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Essentials of Nephrotic Syndrome , Nutshell , Points to Remember Core Concept Points -[ALL ABOUT NEPHROTIC SYNDROME AT A GLANCE]

Essentials of Nephrotic Syndrome , Nutshell , Points to Remember Core Concept Points -[ALL ABOUT NEPHROTIC SYNDROME AT A GLANCE]

Essentials of Nephrotic Syndrome , Nutshell , Points to Remember Core Concept Points -[ALL ABOUT NEPHROTIC SYNDROME AT A GLANCE]

 

What  is Nephrotic Syndrome

Nephrotic syndrome is a kidney disorder that causes the body to excrete too much protein.

Pathophysiology

Podocyte damage leads to loss of
negative charge , which in turn leads to
massive proteinuria.loss of small proteins like albumin and ANP , cause
decrease in serum albumin ( < 3g / dl ) , decrease in ANP make sodium and water retention in the body leads to edema .

Essentials of Nephrotic Syndrome , Nutshell , Points to Remember Core Concept Points -[ALL ABOUT NEPHROTIC SYNDROME AT A GLANCE]

Loss of big protein like protein C/ S leads to increase in clotting factor , venous clot
formation is a risk factor for DEEP
VENOUS THROMBOSIS , RENAL VEIN
THROMBOSIS.

Liver tries to produce protein to overcome
hypoalbuminemia but it leads to increase
in lipid production make hyperlipidemia,
Lipiduria

Take home Points 

Essentials of Nephrotic Syndrome , Nutshell , Points to Remember Core Concept Points -[ALL ABOUT NEPHROTIC SYNDROME AT A GLANCE]

 

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