Must know Points in Calcium Deficiency and Disorders

 Must know Points in Calcium Deficiency and Disorders for FMGE / NEET-PG

As we all know there a Some important Disease etiologies is due to Calcium Deficiency.Now we will see some important information or we can say must know concepts for Calcium Disorders.

OSTEOMALACIA:

  In osteomalacia the serum calcium level is low , the phosphates are low , and alkaline phosphates are low , and alkaline phosphates is high.

Pathophysiology :

  Lack of sunlight exposure, nutritional deficiency of Vitamin D , malabsorption syndrome, partial gastrectomy.

 Failure of absorption of calcium and phosphorus ( decreased serum calcium and phosphorus)

 Decreased turnover of calcium and phosphorus in bone matrix.

 Demineralisation of bone and bony substance replaced by soft osteoid tissue .

 Bone pains , muscular weakness (myopathy), spontaneous fractures.

 

Disease Cause Radiological features
Osteopetrosis Osteoclasts dysfunction Bone within bone appearance

Rugger jersey spine

Osteoporosis Loss of bone mass Cod fish vertebrae

Penicilling – in -vertebrae

Osteogenesis imperfecta Deficiency of synthesis of type1 collagen Thickened or deformed bone due to multiple fractures
Osteomalacia Vitamin D deficiency Looser’s zone or pseudo fracture.
Scurvey Vitamin C deficiency. Frenkel’s line , ring sign , thin cortex , Scurvey line
Rickets Vitamin D deficiency Widening of growth plate , cupping of the metaphysis.