Arterial Blood Gas interpretation:
A case study approach
Arterial Blood Gas interpretation: A case study approach is specially for all the emergency medicine rotators..Explains all the essentials from basics to the most Difficult cases..now you can download the 📖 book.Explains the Basic Physiological PH abnormalities and more to understand..
Arterial Blood Gas interpretation: A case study approach
The purpose of the oxygen dissociation curve is to show the equilibrium of oxyhaemoglobin and non-bonded haemoglobin at various partial pressures. At high partial pressures of oxygen, haemoglobin binds to oxygen to form oxyhaemoglobin. When the blood is fully saturated, all the red blood cells are in the form of oxyhaemoglobin. As the red blood cells travel to tissues deprived of oxygen, the partial pressure of oxygen will decrease. As a consequence of this, the oxyhaemoglobin releases the oxygen to form haemoglobin. The shape of the oxygen dissociation curve is a product of binding of the oxygen to the four polypeptide chains.
A characteristic of haemoglobin is that it has a greater ability to bind oxygen once a sub-unit has bound oxygen. Haemoglobin is therefore most attracted to oxygen when three of the four polypeptide chains are bound to oxygen. This is known as co-operative binding.
The binding of oxygen to haemoglobin can be influenced by a number of factors. An increase in body temperature can denature the bond between oxygen and , thus increasing the amounts of oxygen and haemoglobin but decreasing the amount of bound oxyhaemoglobin. This causes a right shift in the oxygen dissociation curve.