Consultations in Infectious Disease A Case Based Approach to Diagnosis and Management eBook PDF Download
Consultations in Infectious Disease A Case Based Approach to Diagnosis and Management is an Essential clinical referenceBook that is Surely important to Gain the Knowledge and Practice in Internal Medicine.Books of this nature are collaborations of a musical sort. We have felt like conductors working with a worldclass ensemble of musicians, and the end result is a refl ection of their hard work and dedication to this project. We
thank all of our contributors for their evocative storytelling and for the illuminating discussions they have written.
Consultations in Infectious Disease A Case Based Approach to Diagnosis and Management
The high risk and rate of recurrence of invasive N. meningitidis in LCCD indi-
viduals warrants vaccination against meningococcal disease in this group.3
Until recently there was data available only for LCCD patients with the poly-
saccharide vaccine (serogroup A, C, Y and W-135). In a study from Russia,
six new episodes of meningococcal infection developed in four patients in
the group of 31 vaccinees (19%); six episodes in six patients developed in the
same time frame, in the group of 14 nonvaccinated LCCD persons (42%).
Although there are no large studies of patients with late complement defi –
ciency receiving the more recently developed conjugate vaccine (polysac-
charide diphtheria toxoid conjugae, Menactra, Groups A, C, Y and W-135),
serum bactericidal antibodies are higher when compared to the polysaccha-
ride vaccine.Based on expert opinion and the antibody response data, the Advisory Committee on Immunization Practices (ACIP) recommends conjugate vaccine in all patients with late complement defi ciency.
The current recommendation in LCCD patients is revaccination with conjugate vaccine every fi ve years.There is no conclusive data regarding antibiotic prophylaxis in LCCD patients.