Hoffman and Abeloff’s Hematology-Oncology Review First Edition PDF Download
Hoffman and Abeloff’s Hematology-Oncology Review First Edition book is best one for internist and hematology residents with their rotation since this book has only the essential concepts about hematology and their informative also the best one for Exam Preparation like Board exams as well as speciality exam.please support us by sharing our site with your friend’s and Family member’s.
Hoffman and Abeloff’s Hematology-Oncology Review First Edition
There is also direct evidence that BRAF agents do penetrate the blood-brain barrier, which is based on cerebrospinal fluid testing. Therefore, in an asymptomatic patient, it would be reasonable to proceed with BRAF-targeted therapy and monitor the brain lesion on serial imaging studies. Further more, if the brain lesion did eventually increase in size, this would provide more certainty that it is a brain metastasis, and a radiation oncologist or neurosurgeon should offer definitive treatment. There is no clear data indicating that one BRAF plus MEK inhibitor combination is superior to another.
High mutational burden. Overall, immune checkpoint therapies have demonstrated greater clinical activity in tumor types with high mutational burden, such as NSCLC and melanoma. This is thought to be due to the generation of neoantigens that are recognized by the immune system and generate a stronger adaptive immune response.
About the Author
Claudine Isaacs, MD
Professor of Medicine and Oncology
Co-Director, Breast Cancer Program
Medical Director, Fisher Center for Hereditary
Cancer and Clinical Genomics Research
Washington, District of Columbia